جۆری توێژینه‌وه‌: Original Article

نوسه‌ر

Dept. of Chemical Engineering/ College of Engineering / University of Tikrit

پوخته‌

In this study a simple, sensitive and reproducible spectrophotometric method has been
used for determination of trifluoperazine hydrochloride in pure form as well as in
pharmaceutical tablet preparations. This study is adopted on the oxidative coupling reaction
using 4-methoxy aniline as a new chromogenic reagent with ammonium cerium(IV) sulphate
dihydrate as oxidizing agent in acidic medium to form a violet water soluble dye with
absorption at 555 nm. The molar absorptivity 17775 liter / mol .cm and the method obeyed
Lambert-Beer’s law in the concentration range 1.0 – 18.0 μg/ml of TFPH, the relative
standard deviation value ranges from 1.333-1.665 % depending on the concentration level of
TFPH. This study has been applied successfully to the estimation of trifluoperazine
hydrochloride in two pharmaceutical preparations (Iralzin and Salabid tablets).

وشه‌ بنچینه‌ییه‌كان

 

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