Synthesis of Some New Pyrazolines via One-Pot Three Component Technique and Their Corresponding Thiazole Compounds

Hama Salih, Rezan H; Hawaiz, Farouq E

doi:10.24271/garmian.160

Synthesis of Some New Pyrazolines via One-Pot Three Component Technique and Their Corresponding Thiazole Compounds

جۆری توێژینه‌وه‌ : Original Article

نوسه‌ران

Rezan H Hama Salih ¹

Farouq E Hawaiz ²

¹ *Department of Chemistry, College of Education, University of Garmian-Kalar, Kurdistan Region, Iraq.

² Department of Chemistry, College of Education, University of Salahaddin-Hawler, Erbil,Kurdistan Region, Iraq.

https://doi.org/10.24271/garmian.160

پوخته‌

In the present study; a one-pot three component reaction between4(4'-chlorobenzyloxy)
acetophenone , thiosemicarbazide and different substituted benzaldehydes in absolute ethanol
under reflux with stirring has been used to give a new series of pyrazoline derivatives {3-(4-[4'-
chlorobenzyloxy)phenyl)-5-(substituted-phenyl]-4,5-dihydropyrazole-1-carbothioamide}in high
yields and short reaction times. . The later compounds were converted to their corresponding
thiazole derivatives through reacting with 4-bromophenacyl bromide in ethanol. , The structures
of the newly synthesized compounds were identified on the bases of their FT-IR, 1H-NMR, 13C-
NMR and DEPT-135 spectra.

وشه‌ بنچینه‌ییه‌كان

One-pot synthesis

acetophenone. Benzylation

Pyrazoline

Thiazole