Objactive: Cardiovascular disease in diabetes mellitus is an important complications for disease. The mortiality of cardiovascular is five times more in that of an age-matched non-diabetic population. Cell adhesion molecules have been evalute in the initiation and prograssion of atherosclerosis. Methods: (50) diabetic patients (T2DM) were enrolled in the study, and (33) healthy subjects insert in the study as control groups. Serum ICAM-1, insulin hormone, hs-CRP , lipid profile and FPG were masured. Results: there were a significant diffrance in ICAM-1 in patients when compared to control (324.08 ± 15.22 vs. 262.27 ± 22.94 ng/ml, P<0.01). The mean of insulin hormone were (28.93 ± 1.24 vs. 14.67 ± 3.79 , P<0.001 ) for T2DM patients and (160±26 mg/dl) for control and there were a significant difference between them (p< 0.05 ). Conclusion: Serum ICAM-1 levels were significantly increase in diabetic patients and strongly related to early detection for CVD.