جۆری توێژینه‌وه‌: Original Article

نوسه‌ران

1 Department of animal production, faculty of agriculture , university of Garmian

2 Department of Pathology, faculty of veterinary medicine, university of Tikrit

3 Diyala Directorate of general education , Iraq

پوخته‌

The current study was achieved  to investigate for some of biochemical parameters associated with pollution of sheep with petroleum derivatives and it's effects on some parameters of oxidative stress and antioxidant. The blood samples were collected from 70 sheep and divided  into  two groups, the first group included 15 from other city and very far from center of pollution ( about 200 Klm)  which consider as a control group, while  the second group included 55 sheep near the center of pollution ( about 3 Klm)  which represent affection group. The results showed that the affection group cause significant  increase in oxidative stress parameters  (Malondialdehyde , peroxynitrate radical ) (P≤0.05). and we see from this study significant  decrease in antioxidant parameters  (Glutathione, glutathione peroxidase enzyme , superoxide dismutase enzyme ) in the affection group. We can concludes from this study that the Effect of petroleum derivatives impact adversely on antioxidants accompanied by an increase in the level Malondialdehyde and peroxynitrate radical which consider as indicators for oxidative stress that is a companion Effect of petroleum derivatives.

1-        Omoregie, E.. (2010). Effects of water soluble fractions of oil on carbohydrate reserves of Oreochromis niloficus (L). Journal of Aquatic Science. 12:1-7.

2-        Edwards, C.(2008). Toxicology of oil field waste hazards to livestock associated with the petroleum industry. Vet Clin North Am.5:363-374.

3-        Coppock.(2008). Toxicology of oil field pollutants in cattle: A review. Vet Hum Toxicol.37:369-576. 

4-        Uboh F.(2012).Comparative nephrotoxic effect associated with exposure to diesel and gasoline vapours in rats. J Toxicol Environ Health Sci .1:68-74.  

5-        Aboutabl, M.(2012).Inhibition of soluble epoxide hydrolase confers cardioprotection and prevents cardiac cytochrome P450 induction by benzo (a) pyrene. J Cardiovasc Pharmacol.57:273-281.  

6-        Barath, S.(2012).Impaired vascular function after exposure to diesel exhaust generated at urban transient running conditions. Part Fibre Toxicol.7:19.  

7-        Ovuru, S.(2014).Biochemical blood parameters in semi-adult rabbits experimentally fed crude oil contaminated diets. Afr J Biotechnol .3:343-345.

8-          George, M.(2011).Effect of vitamin E on biochemical parameters in albino rats treated with gasoline. J Sci Res.3:641-649

9-        Orisakwe, E.(2014). Investigation into the nephrotoxicity of Nigerian bonny light crude oil in albino rats. Int J Environ Res Public Health .1:106-110

10-    Adebayo, A.(2010).Toxicological evaluation of precocene II isolated from Ageratum conyzoides L. (Asteraceae) in Sprague Dawley rats. Afr J Biotechnol;9:2938-2944   

11-    Beutler, E.(1963). Improved Method for the determination  of  blood GSH J. Lab. And  Clin. Med. 61(5). 882-302.

12-    Gilbert, H. (1984). A method of correct for errors caused by generation of interfering compounds during erythrocyte lipid peroxidation. Analyt. Biochem. 137: 282-286.

13-    Vanuffelen, B.(1998). Biochem. J. 330, 719. Cited by AL-Zamely et al., 2001. The level of malondialdehyde after activation with (H2O2 and CuSO4)  and inhibition by Desferoxamine and Molisidomine in serum of patient with acute myocardial  infarction. National J. of chemistry, 139-148. 5; 2002.

14-    Linder,M. (1996) . Am .J. Clin. Nutr 63: 7775-8115.

15-    Ueno, Y.(2002). Dietary glutathione protects rats from diabetic nephropathy and neutropathy. J. Nutr., 132: 897 - 900.

16-    Bradley, A.(2010).Glutathione metabolism as a determinant of therapeutic efficiency. Cancer Res., 44: 4224-4232

17-    Singhal, R.(2008).Glutathaione, a 1 st Line of defense against cadmium. toxicity. FASEB J., 1: 220-223.

18-    Arise, R.(2013). Assessment of water quality parameters from swamps around Kokori-Erhoike petroleum flow station in Delta State, Nigeria. Der Chemica Sinica, 4(1): 155-161.

19-    Otitoju, O.(2009) . Biomarkers of Pesticide - Contaminated Environment. Pesticides in the Modern World– Pests Control and Pesticides Exposure and Toxicity Assessment. 241–252.

20-    Yildirin, N.(2010).. Evaluation 0f environmental pollution at Munzur River of tunceli applying oxidative stress biomarkers in capoeta trutta . J. Anim. Plant Sci., 21(1): 66-71.

21-    Charissou, A.(2012). Relationship between two oxidative stress biomarkers, malondialdehyde and 8-oxo-7, 8-dihydro-2'-deoxyguanosine, in the freshwater bivalve Unio tumidus. Sci. Total Environ., 322(1-3): 109-122.

22-    Janoff, A.(2011). Effects of tobacco smoke on cellular and biochemical processes in the lung. Am. Rev. Respir. Dis. 136, 1058–1064.