جۆری توێژینهوه : Original Article
نوسهران
1 College of Education for Pure Science, University of Diyala, Iraq
2 King's College London, London, UK
پوخته
Scabies is a contagious skin infection, caused by Sarcoptes scabiei. It is one of a
neglected parasitic disease. It causes complications that lead to inflammatory and
allergic immune response. This study was designed to obtain the role of some
cytokines in scabies patients and compare their levels with dermal diseases patients
and control (healthy).
The study included one hundred and three patients infected with scabies, seven
dermal disease patients (positive controls) as well as 34 healthy individual as control
group. The blood samples were collected from scabies and dermal disease patients as
well as the control groups. Enzyme linked immunosorbent assay (ELISA) was used
to measure Interleukine-4 (IL-4), Interleukin -8 (IL-8), Interleukin-17A (IL-17A),
Tumor necrosis factor-α (TNF-α), Interferon-γ (IFN-γ), Monocyte Chemotactic
Protein-1 (MCP-1) and Macrophage Inflammatory Protein-1-α (MIP-1- α) in the
serum of scabies patients, dermal disease patients and healthy individuals.
The results showed that IL-4, IL-8, IL-17A and TNF- α was higher in scabies
patients than in other groups (positive control and healthy), with no significant
differences. While both of MIP- α and MCP-1 were higher in scabies patients
compared with healthy group, with significant differences. MIP- α was higher in
dermal patients individuals than in scabies patients. TNF- α was lower in scabies
patients than in healthy group but higher than in dermal disease patient group. There
was positive correlation between IL-17A and each of IL-8, TNF- α, MCP-1 and
between IL-8 and both of IL-17A and MCP-1, while there was negative correlation
between MIP-1- α and both of IL-4 and MCP-1. The results suggested that the
scabies infection may induce the systemic and inflammatory immune response.
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