جۆری توێژینه‌وه‌: Original Article

نوسه‌ران

1 * Assistant Lecturer, Medical laboratory Department , Technical Health College, Erbil Polytechnic University, Erbil , Kurdistan Region, Iraq.

2 Assistant prof. , Microbiology Department , Hawler Medical University , Erbil , Kurdistan Region, Iraq.

3 Lecturer, Biology Department , Science College , Misan University, Misan, Iraq.

پوخته‌

Celiac disease (CD) is an autoimmune human leukocyte antigen HLA–
linked enteropathy that develop upon ingestion of gluten containing diet, with
diarrhea, malabsorption and weight loss as a major presentation.
The disease is closely linked to a number of extra intestinal disorder
especially endocrine diseases. This study aimed to assess level of thyroid
stimulation hormone (TSH) and growth hormone (GH) level in patients with newly
diagnosed (ND) CD and on gluten free diet (GFD)
A total of 26/50 newly diagnosed celiac disease patients and 20 on GFD
diagnosed clinically and confirmed serologically using anti-gliadin IgA and IgG
(IgA for diagnosis newly diagnosed and IgG for diagnosis of patients on GFD)
were subjected to TSH and GH level assessment.
The anti-gliadin IgA and IgG were positive in 82% with celiac patients and
80% on GFD patients. Among children , 82.14% of newly diagnosed and 85.71%
on GFD were IgA and IgG anti-gliadin seropositive, while in adults, 81.82% and
76.92 % of newly diagnosed and on GFD were IgA and IgG anti-gliadin
seropositive respectively.
The results revealed elevated TSH level in sera of 80.77% and 30% of CD
and on GFD patients respectively; meanwhile GH level was low in 73.07% and
10% of CD and GFD patients respectively. The frequency CD patients revealed
TSH elevation and low GH in the same patient was 69.23 % and 10% in CD and on
GFD patients respectively.
As a result, the present study delineated simultaneous occurrence and linkage
between CD disease and subclinical hypothyroidism. Beside assessment of GH
level in CD patients is necessary as marker for disorder of pituitary gland, possibly
of autoimmune origin.
In newly diagnosed and patients on GFD patients, no significant correlation exists
between anti-gliadin antibodies, TSH & GH level. Meanwhile significant
correlation was found between TSH & GH in ND (r= - 0.568, P=0.002) & GFD (r=
- 0.702, P= 0.001).

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