جۆری توێژینه‌وه‌ : Original Article

نوسه‌ران

1 *University of Garmian, College of Science, Department of Chemistry, Kurdistan- Iraq.

2 Universiti Teknologi Malaysia, Faculty of Science, Department of Chemistry, UTM Skudai.

پوخته‌

The chalcones and their derivatives are important intermediates in organic synthesis. They serve
as starting material for the synthesis of variety of heterocyclic compounds which are of physio-
logical importance. In this study, two hydroxylated chalcone named as (2′,4′,4-
trihydroxychalcone and 4′,4-dihydroxychalcone) together with 2′,4′,4,6′-tetrahydroxy-3′-
prenylchalcone were synthesized by Claisen-Schmidt condensation of various hydroxyacetophe-
none and 2,4,6-trihydroxy-3-C-prenylacetophenone for prenylated chalcone with 4-
hydroxybenzaldyhe using BF3.Et2O. The structures of all compounds were characterized using
spectroscopic methods (NMR and IR).

وشه‌ بنچینه‌ییه‌كان

 
1.  Manmohan, S., Arindam, P. and Pratap, S. H.  (2011). Synthesis and Characterization of Some Novel Chalcone Derivatives: An Intermediate for Various Heterocyclics Compounds. International journal of pharmaceutical innovations, 1(1), 1-7.
2.  Shamaun, S. S., Rahmani, M., Hashim, N. M., Ismail, H. B. M., Sukari, M. A., Lian, G. E. C. and Go, R. (2010). Prenylated flavones from Artocarpus altilisJournal of natural medicines64(4), 478-481.
3.  Jayasinghe, L., Balasooriya, B. A. I S., Padmini, W. C., Hara, N. and Fujimoto, Y. (2004). Geranyl chalcone derivatives with antifungal and radical scavenging properties from the leaves of Artocarpus nobilis. Phytochemistry65(9), 1287–1290.
4.  Abegaz, B. M., Ngadjui, B.T., Dongo, E. and  Tamboue, H. (1998). Prenylated Chalcones And Flavones From The Leaves of Dorstenia KamerunianaPhytochemistry, 49(4), 1147-1150.
5.  Kochummen, K. M. and Go, R. (2000). Moraceae. In Tree Flora Sabah and Sarawak; Ampang Press: Kuala Lumpur, Malaysia, 181–212.
6.  Hakim, E. H., Achmad, S. A., Juliawaty, L. D., Makmur, L., Syah, Y. M., Aimi, N., Kitajima, M., Takayama, H. and Ghisalberti, E.L. (2006). Prenylated flavonoids and related compounds of the Indonesian Artocarpus (Moraceae), Journal of Natural Medicines60(3), 161–184.
7.  Jamil, S., Sirat, H. M., Jantan, I., Aimi, N. and Kitajima, M. (2008). A New Prenylated Dihydrochalcone From The Leaves of Artocarpus LowiiJournal of natural medicines62(3), 321-324.
8.  Fang, S. C., Hsu, C. L., Yu, Y. S. and Yen, G. C. (2008). Cytotoxic effects of new geranyl chalcone derivatives isolated from the leaves of Artocarpus communis in SW 872 human liposarcoma cells. Journal of agricultural and food chemistry56(19), 8859-8868. 
9.  Narender, T. and Papi Reddy, K. (2007). A simple and highly efficient method for the synthesis of chalcones by using borontrifluoride-etherate. Tetrahedron letters48(18), 3177-3180.
10.  Solomons, T., W., G. and Fryhl, C. (2009). Organic Chemistry. (10th Ed). Wiley: 103-104